Sandra B. Gabelli, Ph.D.
My research is aimed at elucidating the molecular mechanism of proteins involved in cell signaling pathways modulated by the second messenger phosphatidylinositol 3,4,5 triphosphate, (PIP3). To achieve a comprehensive understanding I am studying cytoplasmic protein-protein interactions involved in regulation of pathways such as PI3K and Na transporters. Many of these pathways are deregulated in diseases such as diarrhea, diabetes, inflammation and cancer. I seek to understand the structural basis of deregulation as a lead to design inhibitors for targeted therapies. My research integrates structural biology and chemical biology and it is focused on drug discovery. As part of the Structural Enzymology and Thermodynamics Group we use biochemical and biophysical techniques including X-ray crystallography, SAXS, ITC, Mass spectrometry, AUC.