1. Aytenfisu, TY, Campbell, HM, Chakrabarti, M, Amzel, LM, Gabelli, SB. Class I PI3K Biology. Curr Top Microbiol Immunol. 2022;436 :3-49. doi: 10.1007/978-3-031-06566-8_1. PubMed PMID:36243838 .
  2. Sengupta, S, Board, NL, Wu, F, Moskovljevic, M, Douglass, J, Zhang, J et al.. TCR-mimic bispecific antibodies to target the HIV-1 reservoir. Proc Natl Acad Sci U S A. 2022;119 (15):e2123406119. doi: 10.1073/pnas.2123406119. PubMed PMID:35394875 PubMed Central PMC9169739.
  3. Jiang, H, Chiang, CY, Chen, Z, Nathan, S, D'Agostino, G, Paulo, JA et al.. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates. J Biol Chem. 2022;298 (5):101854. doi: 10.1016/j.jbc.2022.101854. PubMed PMID:35331737 PubMed Central PMC9034101.
  4. Nguyen, T, Phan, KL, Kozakov, D, Gabelli, SB, Kreitler, DF, Andrews, LC et al.. A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs. Acta Crystallogr D Struct Biol. 2022;78 (Pt 3):268-277. doi: 10.1107/S2059798321013425. PubMed PMID:35234141 PubMed Central PMC8900820.
  5. Juhaszova, M, Kobrinsky, E, Zorov, DB, Nuss, HB, Yaniv, Y, Fishbein, KW et al.. ATP Synthase K+- and H+-Fluxes Drive ATP Synthesis and Enable Mitochondrial K+-"Uniporter" Function: I. Characterization of Ion Fluxes. Function (Oxf). 2022;3 (2):zqab065. doi: 10.1093/function/zqab065. PubMed PMID:35229078 PubMed Central PMC8867323.
  6. Srinivasan, L, Alzogaray, V, Selvakumar, D, Nathan, S, Yoder, JB, Wright, KM et al.. Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms. J Biol Chem. 2022;298 (4):101763. doi: 10.1016/j.jbc.2022.101763. PubMed PMID:35202650 PubMed Central PMC8935509.
  7. Juhaszova, M, Kobrinsky, E, Zorov, DB, Nuss, HB, Yaniv, Y, Fishbein, KW et al.. ATP Synthase K+- and H+-fluxes Drive ATP Synthesis and Enable Mitochondrial K+-"Uniporter" Function: II. Ion and ATP Synthase Flux Regulation. Function (Oxf). 2022;3 (2):zqac001. doi: 10.1093/function/zqac001. PubMed PMID:35187492 PubMed Central PMC8850977.
  8. Pearlman, AH, Hwang, MS, Konig, MF, Hsiue, EH, Douglass, J, DiNapoli, SR et al.. Author Correction: Targeting public neoantigens for cancer immunotherapy. Nat Cancer. 2021;2 (8):865-867. doi: 10.1038/s43018-021-00246-0. PubMed PMID:35122030 .
  9. Salguero, AL, Chen, M, Balana, AT, Chu, N, Jiang, H, Palanski, BA et al.. Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications. ACS Chem Biol. 2022;17 (1):68-76. doi: 10.1021/acschembio.1c00632. PubMed PMID:34941261 PubMed Central PMC8864695.
  10. Ma, Q, Srinivasan, L, Gabelli, SB, Raben, DM. Elusive structure of mammalian DGKs. Adv Biol Regul. 2022;83 :100847. doi: 10.1016/j.jbior.2021.100847. PubMed PMID:34922895 PubMed Central PMC8858910.
  11. Pearlman, AH, Hwang, MS, Konig, MF, Hsiue, EH, Douglass, J, DiNapoli, SR et al.. Targeting public neoantigens for cancer immunotherapy. Nat Cancer. 2021;2 (5):487-497. doi: 10.1038/s43018-021-00210-y. PubMed PMID:34676374 PubMed Central PMC8525885.
  12. Dempsey, DR, Viennet, T, Iwase, R, Park, E, Henriquez, S, Chen, Z et al.. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021;28 (10):858-868. doi: 10.1038/s41594-021-00668-5. PubMed PMID:34625746 PubMed Central PMC8549118.
  13. Hwang, MS, Miller, MS, Thirawatananond, P, Douglass, J, Wright, KM, Hsiue, EH et al.. Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. Nat Commun. 2021;12 (1):5271. doi: 10.1038/s41467-021-25605-4. PubMed PMID:34489470 PubMed Central PMC8421441.
  14. Nathan, S, Gabelli, SB. Navigating the intricacies of cellular machinery. J Biol Chem. 2021;296 :100832. doi: 10.1016/j.jbc.2021.100832. PubMed PMID:34048713 PubMed Central PMC8214083.
  15. Hwang, MS, Mog, BJ, Douglass, J, Pearlman, AH, Hsiue, EH, Paul, S et al.. Targeting loss of heterozygosity for cancer-specific immunotherapy. Proc Natl Acad Sci U S A. 2021;118 (12):. doi: 10.1073/pnas.2022410118. PubMed PMID:33731480 PubMed Central PMC8000272.
  16. Paul, S, Pearlman, AH, Douglass, J, Mog, BJ, Hsiue, EH, Hwang, MS et al.. TCR β chain-directed bispecific antibodies for the treatment of T cell cancers. Sci Transl Med. 2021;13 (584):. doi: 10.1126/scitranslmed.abd3595. PubMed PMID:33649188 PubMed Central PMC8236299.
  17. Hsiue, EH, Wright, KM, Douglass, J, Hwang, MS, Mog, BJ, Pearlman, AH et al.. Targeting a neoantigen derived from a common TP53 mutation. Science. 2021;371 (6533):. doi: 10.1126/science.abc8697. PubMed PMID:33649166 PubMed Central PMC8208645.
  18. Douglass, J, Hsiue, EH, Mog, BJ, Hwang, MS, DiNapoli, SR, Pearlman, AH et al.. Bispecific antibodies targeting mutant RAS neoantigens. Sci Immunol. 2021;6 (57):. doi: 10.1126/sciimmunol.abd5515. PubMed PMID:33649101 PubMed Central PMC8141259.
  19. Nathan, S, Gabelli, SB, Yoder, JB, Srinivasan, L, Aldrich, RW, Tomaselli, GF et al.. Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation. J Gen Physiol. 2021;153 (1):. doi: 10.1085/jgp.202012722. PubMed PMID:33306788 PubMed Central PMC7953540.
  20. Dunston, TT, Khomutov, MA, Gabelli, SB, Stewart, TM, Foley, JR, Kochetkov, SN et al.. Identification of a Novel Substrate-Derived Spermine Oxidase Inhibitor. Acta Naturae. 2020;12 (3):140-144. doi: 10.32607/actanaturae.10992. PubMed PMID:33173604 PubMed Central PMC7604895.
  21. Maheshwari, S, Kim, YS, Aripirala, S, Murphy, M, Amzel, LM, Gabelli, SB et al.. Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase. Biochemistry. 2020;59 (29):2751-2759. doi: 10.1021/acs.biochem.0c00432. PubMed PMID:32584028 PubMed Central PMC8049779.
  22. Chang, TH, Hsieh, FL, Smallwood, PM, Gabelli, SB, Nathans, J. Structure of the RECK CC domain, an evolutionary anomaly. Proc Natl Acad Sci U S A. 2020;117 (26):15104-15111. doi: 10.1073/pnas.2006332117. PubMed PMID:32541044 PubMed Central PMC7334487.
  23. Branco Santos, JC, de Melo, JA, Maheshwari, S, de Medeiros, WMTQ, de Freitas Oliveira, JW, Moreno, CJ et al.. Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs. Molecules. 2020;25 (11):. doi: 10.3390/molecules25112602. PubMed PMID:32503272 PubMed Central PMC7321420.
  24. Chakrabarti, M, Gabelli, SB, Amzel, LM. Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations. Structure. 2020;28 (4):465-474.e5. doi: 10.1016/j.str.2020.01.010. PubMed PMID:32049032 PubMed Central PMC8057532.
  25. Miller, MS, Douglass, J, Hwang, MS, Skora, AD, Murphy, M, Papadopoulos, N et al.. An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation. J Biol Chem. 2019;294 (50):19322-19334. doi: 10.1074/jbc.RA119.010251. PubMed PMID:31690625 PubMed Central PMC6916501.
  26. Thirawatananond, P, McPherson, RL, Malhi, J, Nathan, S, Lambrecht, MJ, Brichacek, M et al.. Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep. 2019;9 (1):5940. doi: 10.1038/s41598-019-39491-w. PubMed PMID:30976021 PubMed Central PMC6459841.
  27. Yoder, JB, Ben-Johny, M, Farinelli, F, Srinivasan, L, Shoemaker, SR, Tomaselli, GF et al.. Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat Commun. 2019;10 (1):1514. doi: 10.1038/s41467-019-09570-7. PubMed PMID:30944319 PubMed Central PMC6447637.
  28. Miller, MS, Thompson, PE, Gabelli, SB. Structural Determinants of Isoform Selectivity in PI3K Inhibitors. Biomolecules. 2019;9 (3):. doi: 10.3390/biom9030082. PubMed PMID:30813656 PubMed Central PMC6468644.
  29. Miller, MS, Maheshwari, S, Shi, W, Gao, Y, Chu, N, Soares, AS et al.. Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules. 2019;24 (3):. doi: 10.3390/molecules24030496. PubMed PMID:30704096 PubMed Central PMC6384729.
  30. Ma, Q, Gabelli, SB, Raben, DM. Diacylglycerol kinases: Relationship to other lipid kinases. Adv Biol Regul. 2019;71 :104-110. doi: 10.1016/j.jbior.2018.09.014. PubMed PMID:30348515 PubMed Central PMC6347529.
  31. Maheshwari, S, Shimokawa, C, Rudzka, K, Kline, CD, Eipper, BA, Mains, RE et al.. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase. Commun Biol. 2018;1 :74. doi: 10.1038/s42003-018-0082-y. PubMed PMID:30271955 PubMed Central PMC6123673.
  32. Chu, N, Salguero, AL, Liu, AZ, Chen, Z, Dempsey, DR, Ficarro, SB et al.. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018;174 (4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. PubMed PMID:30078705 PubMed Central PMC6139374.
  33. Banerjee, R, Yoder, JB, Yue, DT, Amzel, LM, Tomaselli, GF, Gabelli, SB et al.. Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels. Proc Natl Acad Sci U S A. 2018;115 (13):E3026-E3035. doi: 10.1073/pnas.1716381115. PubMed PMID:29531055 PubMed Central PMC5879666.
  34. Shumar, SA, Kerr, EW, Geldenhuys, WJ, Montgomery, GE, Fagone, P, Thirawatananond, P et al.. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem. 2018;293 (11):4134-4148. doi: 10.1074/jbc.RA117.001358. PubMed PMID:29378847 PubMed Central PMC5857999.
  35. Nakamura, H, Lee, AA, Afshar, AS, Watanabe, S, Rho, E, Razavi, S et al.. Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nat Mater. 2018;17 (1):79-89. doi: 10.1038/nmat5006. PubMed PMID:29115293 PubMed Central PMC5916848.
  36. Chatterjee, S, Lesniak, WG, Miller, MS, Lisok, A, Sikorska, E, Wharram, B et al.. Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263]. Biochem Biophys Res Commun. 2017;491 (4):1125. doi: 10.1016/j.bbrc.2017.08.001. PubMed PMID:28801167 PubMed Central PMC5600467.
  37. Maheshwari, S, Miller, MS, O'Meally, R, Cole, RN, Amzel, LM, Gabelli, SB et al.. Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition. J Biol Chem. 2017;292 (33):13541-13550. doi: 10.1074/jbc.M116.772426. PubMed PMID:28676499 PubMed Central PMC5566514.
  38. Chen, Z, Jiang, H, Xu, W, Li, X, Dempsey, DR, Zhang, X et al.. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017;66 (3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020. PubMed PMID:28475870 PubMed Central PMC5489419.
  39. Miller, MS, Maheshwari, S, McRobb, FM, Kinzler, KW, Amzel, LM, Vogelstein, B et al.. Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. Bioorg Med Chem. 2017;25 (4):1481-1486. doi: 10.1016/j.bmc.2017.01.012. PubMed PMID:28129991 PubMed Central PMC5319926.
  40. Chatterjee, S, Lesniak, WG, Miller, MS, Lisok, A, Sikorska, E, Wharram, B et al.. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. 2017;483 (1):258-263. doi: 10.1016/j.bbrc.2016.12.156. PubMed PMID:28025143 PubMed Central PMC5253331.
  41. O'Handley, SF, Thirawatananond, P, Kang, LW, Cunningham, JE, Leyva, JA, Amzel, LM et al.. Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis. J Bioenerg Biomembr. 2016;48 (6):557-567. doi: 10.1007/s10863-016-9681-9. PubMed PMID:27683242 PubMed Central PMC5489420.
  42. Daniels, CM, Thirawatananond, P, Ong, SE, Gabelli, SB, Leung, AK. Nudix hydrolases degrade protein-conjugated ADP-ribose. Sci Rep. 2015;5 :18271. doi: 10.1038/srep18271. PubMed PMID:26669448 PubMed Central PMC4680915.
  43. de la Peña, AH, Suarez, A, Duong-Ly, KC, Schoeffield, AJ, Pizarro-Dupuy, MA, Zarr, M et al.. Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus. PLoS One. 2015;10 (11):e0141716. doi: 10.1371/journal.pone.0141716. PubMed PMID:26524597 PubMed Central PMC4629899.
  44. Gabelli, SB, Yoder, JB, Tomaselli, GF, Amzel, LM. Calmodulin and Ca(2+) control of voltage gated Na(+) channels. Channels (Austin). 2016;10 (1):45-54. doi: 10.1080/19336950.2015.1075677. PubMed PMID:26218606 PubMed Central PMC4802738.
  45. Skora, AD, Douglass, J, Hwang, MS, Tam, AJ, Blosser, RL, Gabelli, SB et al.. Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes. Proc Natl Acad Sci U S A. 2015;112 (32):9967-72. doi: 10.1073/pnas.1511996112. PubMed PMID:26216968 PubMed Central PMC4538619.
  46. Echeverria, I, Liu, Y, Gabelli, SB, Amzel, LM. Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α. FEBS J. 2015;282 (18):3528-42. doi: 10.1111/febs.13365. PubMed PMID:26122737 PubMed Central PMC4573839.
  47. Duong-Ly, KC, Gabelli, SB. Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag. Methods Enzymol. 2015;559 :17-26. doi: 10.1016/bs.mie.2014.11.004. PubMed PMID:26096500 PubMed Central PMC4612625.
  48. Wolff, KA, de la Peña, AH, Nguyen, HT, Pham, TH, Amzel, LM, Gabelli, SB et al.. A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development. PLoS Pathog. 2015;11 (4):e1004839. doi: 10.1371/journal.ppat.1004839. PubMed PMID:25884716 PubMed Central PMC4401782.
  49. Gabelli, SB, Boto, A, Kuhns, VH, Bianchet, MA, Farinelli, F, Aripirala, S et al.. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun. 2014;5 :5126. doi: 10.1038/ncomms6126. PubMed PMID:25370050 PubMed Central PMC4223872.
  50. Gabelli, SB, Echeverria, I, Alexander, M, Duong-Ly, KC, Chaves-Moreira, D, Brower, ET et al.. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects. Biophys Rev. 2014;6 (1):89-95. doi: 10.1007/s12551-013-0131-1. PubMed PMID:25309634 PubMed Central PMC4192660.
  51. Miller, MS, Schmidt-Kittler, O, Bolduc, DM, Brower, ET, Chaves-Moreira, D, Allaire, M et al.. Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget. 2014;5 (14):5198-208. doi: 10.18632/oncotarget.2263. PubMed PMID:25105564 PubMed Central PMC4170646.
  52. Duong-Ly, KC, Gabelli, SB. Explanatory chapter: troubleshooting protein expression: what to do when the protein is not soluble. Methods Enzymol. 2014;541 :231-47. doi: 10.1016/B978-0-12-420119-4.00018-5. PubMed PMID:24674075 .
  53. Duong-Ly, KC, Gabelli, SB. Explanatory chapter: troubleshooting recombinant protein expression: general. Methods Enzymol. 2014;541 :209-29. doi: 10.1016/B978-0-12-420119-4.00017-3. PubMed PMID:24674074 .
  54. Duong-Ly, KC, Gabelli, SB. Gel filtration chromatography (size exclusion chromatography) of proteins. Methods Enzymol. 2014;541 :105-14. doi: 10.1016/B978-0-12-420119-4.00009-4. PubMed PMID:24674066 .
  55. Duong-Ly, KC, Gabelli, SB. Using ion exchange chromatography to purify a recombinantly expressed protein. Methods Enzymol. 2014;541 :95-103. doi: 10.1016/B978-0-12-420119-4.00008-2. PubMed PMID:24674065 .
  56. Duong-Ly, KC, Gabelli, SB. Salting out of proteins using ammonium sulfate precipitation. Methods Enzymol. 2014;541 :85-94. doi: 10.1016/B978-0-12-420119-4.00007-0. PubMed PMID:24674064 .
  57. Aripirala, S, Gonzalez-Pacanowska, D, Oldfield, E, Kaiser, M, Amzel, LM, Gabelli, SB et al.. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallogr D Biol Crystallogr. 2014;70 (Pt 3):802-10. doi: 10.1107/S1399004713033221. PubMed PMID:24598749 PubMed Central PMC3949514.
  58. Bolduc, D, Rahdar, M, Tu-Sekine, B, Sivakumaren, SC, Raben, D, Amzel, LM et al.. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2013;2 :e00691. doi: 10.7554/eLife.00691. PubMed PMID:23853711 PubMed Central PMC3707082.
  59. Duong-Ly, KC, Woo, HN, Dunn, CA, Xu, W, Babič, A, Bessman, MJ et al.. A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis. PLoS One. 2013;8 (5):e64241. doi: 10.1371/journal.pone.0064241. PubMed PMID:23691178 PubMed Central PMC3655063.
  60. Zhang, F, Bhat, S, Gabelli, SB, Chen, X, Miller, MS, Nacev, BA et al.. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem. 2013;56 (10):3996-4016. doi: 10.1021/jm400227z. PubMed PMID:23634668 PubMed Central PMC3714011.
  61. Zhang, P, Yang, X, Zhang, F, Gabelli, SB, Wang, R, Zhang, Y et al.. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem. 2013;21 (9):2600-17. doi: 10.1016/j.bmc.2013.02.023. PubMed PMID:23507151 PubMed Central PMC3688283.
  62. Aripirala, S, Szajnman, SH, Jakoncic, J, Rodriguez, JB, Docampo, R, Gabelli, SB et al.. Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J Med Chem. 2012;55 (14):6445-54. doi: 10.1021/jm300425y. PubMed PMID:22715997 PubMed Central PMC4710095.
  63. Boto, AN, Xu, W, Jakoncic, J, Pannuri, A, Romeo, T, Bessman, MJ et al.. Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins. 2011;79 (8):2455-66. doi: 10.1002/prot.23069. PubMed PMID:21638333 PubMed Central PMC3164844.
  64. Duong-Ly, KC, Gabelli, SB, Xu, W, Dunn, CA, Schoeffield, AJ, Bessman, MJ et al.. The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. J Bacteriol. 2011;193 (13):3175-85. doi: 10.1128/JB.00089-11. PubMed PMID:21531795 PubMed Central PMC3133267.
  65. Schmidt-Kittler, O, Zhu, J, Yang, J, Liu, G, Hendricks, W, Lengauer, C et al.. PI3Kα inhibitors that inhibit metastasis. Oncotarget. 2010;1 (5):339-48. doi: 10.18632/oncotarget.166. PubMed PMID:21179398 PubMed Central PMC3004370.
  66. Gabelli, SB, Duong-Ly, KC, Brower, ET, Amzel, LM. Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase. Adv Enzyme Regul. 2011;51 (1):273-9. doi: 10.1016/j.advenzreg.2010.09.013. PubMed PMID:21035489 PubMed Central PMC3079044.
  67. Messing, SA, Gabelli, SB, Echeverria, I, Vogel, JT, Guan, JC, Tan, BC et al.. Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell. 2010;22 (9):2970-80. doi: 10.1105/tpc.110.074815. PubMed PMID:20884803 PubMed Central PMC2965545.
  68. Mohan, S, Tse, CM, Gabelli, SB, Sarker, R, Cha, B, Fahie, K et al.. NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. J Biol Chem. 2010;285 (45):34566-78. doi: 10.1074/jbc.M110.165712. PubMed PMID:20736165 PubMed Central PMC2966072.
  69. Gabelli, SB, Huang, CH, Mandelker, D, Schmidt-Kittler, O, Vogelstein, B, Amzel, LM et al.. Structural effects of oncogenic PI3Kα mutations. Curr Top Microbiol Immunol. 2010;347 :43-53. doi: 10.1007/82_2010_53. PubMed PMID:20593314 PubMed Central PMC3172713.
  70. Barrila, J, Gabelli, SB, Bacha, U, Amzel, LM, Freire, E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry. 2010;49 (20):4308-17. doi: 10.1021/bi1002585. PubMed PMID:20420403 PubMed Central PMC2877132.
  71. Gabelli, SB, Mandelker, D, Schmidt-Kittler, O, Vogelstein, B, Amzel, LM. Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. Biochim Biophys Acta. 2010;1804 (3):533-40. doi: 10.1016/j.bbapap.2009.11.020. PubMed PMID:19962457 PubMed Central PMC2821964.
  72. Huang, CH, Gabelli, SB, Oldfield, E, Amzel, LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 2010;78 (4):888-99. doi: 10.1002/prot.22614. PubMed PMID:19876942 PubMed Central PMC3018326.
  73. Mandelker, D, Gabelli, SB, Schmidt-Kittler, O, Zhu, J, Cheong, I, Huang, CH et al.. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009;106 (40):16996-7001. doi: 10.1073/pnas.0908444106. PubMed PMID:19805105 PubMed Central PMC2761334.
  74. Messing, SA, Gabelli, SB, Liu, Q, Celesnik, H, Belasco, JG, Piñeiro, SA et al.. Structure and biological function of the RNA pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus. Structure. 2009;17 (3):472-81. doi: 10.1016/j.str.2008.12.022. PubMed PMID:19278661 PubMed Central PMC2993163.
  75. Steyert, SR, Messing, SA, Amzel, LM, Gabelli, SB, Piñeiro, SA. Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase. J Bacteriol. 2008;190 (24):8215-9. doi: 10.1128/JB.01009-08. PubMed PMID:18931106 PubMed Central PMC2593198.
  76. Amzel, LM, Huang, CH, Mandelker, D, Lengauer, C, Gabelli, SB, Vogelstein, B et al.. Structural comparisons of class I phosphoinositide 3-kinases. Nat Rev Cancer. 2008;8 (9):665-9. doi: 10.1038/nrc2443. PubMed PMID:18633356 PubMed Central PMC2847604.
  77. Bacha, U, Barrila, J, Gabelli, SB, Kiso, Y, Mario Amzel, L, Freire, E et al.. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008;72 (1):34-49. doi: 10.1111/j.1747-0285.2008.00679.x. PubMed PMID:18611220 PubMed Central PMC2597651.
  78. Huang, CH, Mandelker, D, Gabelli, SB, Amzel, LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle. 2008;7 (9):1151-6. doi: 10.4161/cc.7.9.5817. PubMed PMID:18418043 PubMed Central PMC3260475.
  79. Huang, CH, Mandelker, D, Schmidt-Kittler, O, Samuels, Y, Velculescu, VE, Kinzler, KW et al.. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science. 2007;318 (5857):1744-8. doi: 10.1126/science.1150799. PubMed PMID:18079394 .
  80. Gabelli, SB, Bianchet, MA, Xu, W, Dunn, CA, Niu, ZD, Amzel, LM et al.. Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. Structure. 2007;15 (8):1014-22. doi: 10.1016/j.str.2007.06.018. PubMed PMID:17698004 .
  81. Gabelli, SB, Azurmendi, HF, Bianchet, MA, Amzel, LM, Mildvan, AS. X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction. Biochemistry. 2006;45 (38):11290-303. doi: 10.1021/bi061239g. PubMed PMID:16981689 .
  82. Gabelli, SB, McLellan, JS, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, LM et al.. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins. 2006;62 (1):80-8. doi: 10.1002/prot.20754. PubMed PMID:16288456 .
  83. Nadella, M, Bianchet, MA, Gabelli, SB, Barrila, J, Amzel, LM. Structure and activity of the axon guidance protein MICAL. Proc Natl Acad Sci U S A. 2005;102 (46):16830-5. doi: 10.1073/pnas.0504838102. PubMed PMID:16275926 PubMed Central PMC1277968.
  84. Coblitz, B, Shikano, S, Wu, M, Gabelli, SB, Cockrell, LM, Spieker, M et al.. C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. J Biol Chem. 2005;280 (43):36263-72. doi: 10.1074/jbc.M507559200. PubMed PMID:16123035 .
  85. Xia, Z, Azurmendi, HF, Lairson, LL, Withers, SG, Gabelli, SB, Bianchet, MA et al.. Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. Biochemistry. 2005;44 (25):8989-97. doi: 10.1021/bi050583v. PubMed PMID:15966723 .
  86. Mildvan, AS, Xia, Z, Azurmendi, HF, Saraswat, V, Legler, PM, Massiah, MA et al.. Structures and mechanisms of Nudix hydrolases. Arch Biochem Biophys. 2005;433 (1):129-43. doi: 10.1016/j.abb.2004.08.017. PubMed PMID:15581572 .
  87. Gabelli, SB, Bianchet, MA, Azurmendi, HF, Xia, Z, Sarawat, V, Mildvan, AS et al.. Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus. Structure. 2004;12 (6):927-35. doi: 10.1016/j.str.2004.03.028. PubMed PMID:15274914 .
  88. Kang, LW, Gabelli, SB, Cunningham, JE, O'Handley, SF, Amzel, LM. Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis. Structure. 2003;11 (8):1015-23. doi: 10.1016/s0969-2126(03)00154-0. PubMed PMID:12906832 .
  89. Kang, LW, Gabelli, SB, Bianchet, MA, Xu, WL, Bessman, MJ, Amzel, LM et al.. Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family. J Bacteriol. 2003;185 (14):4110-8. doi: 10.1128/JB.185.14.4110-4118.2003. PubMed PMID:12837785 PubMed Central PMC164880.
  90. Cho, HS, Mason, K, Ramyar, KX, Stanley, AM, Gabelli, SB, Denney, DW Jr et al.. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003;421 (6924):756-60. doi: 10.1038/nature01392. PubMed PMID:12610629 .
  91. Gabelli, SB, Bianchet, MA, Ohnishi, Y, Ichikawa, Y, Bessman, MJ, Amzel, LM et al.. Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Biochemistry. 2002;41 (30):9279-85. doi: 10.1021/bi0259296. PubMed PMID:12135348 .
  92. Gabelli, SB, Bianchet, MA, Bessman, MJ, Amzel, LM. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Nat Struct Biol. 2001;8 (5):467-72. doi: 10.1038/87647. PubMed PMID:11323725 .
Search PubMed