Molecular mechanisms of deregulation in cancer and cardiovascular disease

We are interested on studying molecular abnormalities that underlie diseases to design targeted molecular therapies.  Specifically, alterations in the regulation and protein:protein interaction due to mutations are implicated from cardiovascular disease to cancer.  Understanding the structural and mechanistic details of each signaling event and the protein-protein interactions involved is our key to design the next generation of targeted therapies. We use techniques from biophysics with an emphasis in structural biology: biochemistry, cell-based assay, X-ray crystallography, cryo-eM, SAXS, ITC, SPR, to test the proof of principle of therapies.

As part of the Structural Enzymology and Thermodynamics Group we use an array of techniques from biochemistry, assay development, X-ray crystallography, SAXS, chemical biology, ITC, SPR, and fluorescence.

Structural Basis of Mechanisms of Activation and Inhibition of PI3Kα Signaling Pathway

The PI3K-AKT signaling pathway is one of the most frequently dysregulated pathways in human cancers. Our goal is to design...

HECT E3 Ligases

Members of the NEDD4 HECT E3 ligase family ubiquitinate and downregulate signaling molecules of the PI3K pathway such as EGFR...

Regulation of Voltage Gated Channels

Voltage-gated sodium channels are responsible for the action potential in excitable cells such as neuron, cardiac and skeletal muscle.  We...

Versatility of the Nudix Enzymes

Nudix hydrolases are a superfamily of pyrophospho-hydrolases catalyzing the hydrolysis of a nucleoside diphosphate linked to different moieties. Some of...

Farnesyl Diphosphate Synthase as a Target for Parasitic Disease

Bisphosphonates, drugs used to treat bone resorption, have been shown to have an antiparasitic effect. In humans, they act by...

Structure-based design of Inmunotherapies

We are exploiting the genetic aberrations that drive tumorigenesis to design personalized therapeutics by targeting the commonly mutated cancer driver...