Molecular mechanisms of deregulation in cancer and cardiovascular disease
We are interested on studying molecular abnormalities that underlie diseases to design targeted molecular therapies. Specifically, alterations in the regulation and protein:protein interaction due to mutations are implicated from cardiovascular disease to cancer. Understanding the structural and mechanistic details of each signaling event and the protein-protein interactions involved is our key to design the next generation of targeted therapies. We use techniques from biophysics with an emphasis in structural biology: biochemistry, cell-based assay, X-ray crystallography, cryo-eM, SAXS, ITC, SPR, to test the proof of principle of therapies.
As part of the Structural Enzymology and Thermodynamics Group we use an array of techniques from biochemistry, assay development, X-ray crystallography, SAXS, chemical biology, ITC, SPR, and fluorescence.
The PI3K-AKT signaling pathway is one of the most frequently dysregulated pathways in human cancers. Our goal is to design...