The focus of our research is on structural, mechanistic and functional aspects of enzyme activation that play a role in biology of human disease such as cancer, parasitic infection and cardiovascular disease. We seek to understand how molecular events at the recognition level coordinate and trigger events in cells. Towards that end we are focusing our work on cytoplasmic protein-protein interactions and their regulation by posttranslational modifications. Specifically, we are studying the regulation of the PI3K pathway, the activation of voltage gated sodium channels and the regulation of metabolites by Nudix enzymes and farnesyl diphosphate synthases.
As part of the Structural Enzymology and Thermodynamics Group we use an array of techniques from biochemistry, assay development, X-ray crystallography, SAXS, chemical biology, ITC, SPR, and fluorescence.