HECT E3 Ligases

Members of the NEDD4 HECT E3 ligase family ubiquitinate and downregulate signaling molecules of the PI3K pathway such as EGFR (NEDD4), PTEN (WWP2), AKT1 (), PI3Ka (NEDD4-2) as well as the voltage gated sodium channels (NEDD4-2). We are interested on stablishing the structural basis of NEDD4s regulation as well as their substrate specificity.